LENTIVIRAL VECTOR SCIENTIFIC CONSULTING
Move your LV program forward.
Know what to test next.
Independent lentiviral vector consulting for biotech, cell and gene therapy, and research teams. Resolve titer variability, understand recovery losses, and plan scale-up with a clearer technical strategy.
VECTOR DEVELOPMENT
From particle production to functional performance.
Connect process variables, product attributes, analytical readouts and biological function to make development decisions with greater confidence.
THE LENTIWORKS APPROACH
A clearer path from data to your next decision.
Lentiviral vector performance is not defined by a single number. LentiWorks helps connect production, purification, particle quality, functional activity and analytical data into a practical development strategy.
Whether troubleshooting inconsistent functional titer, evaluating a new production condition, developing a characterization package or preparing for scale-up, the goal is to identify what matters, test it efficiently and turn data into an actionable path forward.
START WITH YOUR BOTTLENECK
Where is your program getting stuck?
You do not need a fully defined scope. Start with the development question your team needs to answer.
Explore all consulting servicesParticle counts look good. Functional titer does not.
Connect analytical readouts to biological performance and prioritize the next investigation.
Discuss titer & analyticsVector recovery drops during purification.
Review process steps, recovery tradeoffs, and measurements to target potential sources of loss.
Discuss downstream recoveryThe next scale brings new uncertainty.
Map process risks and evidence gaps before committing to larger-scale development.
Discuss scale-up readinessCORE CAPABILITIES
Consulting across the LV development lifecycle.
Upstream Development
Production strategy, transient transfection, HEK293 systems, process optimization and scale considerations.
→ 02Downstream & Purification
Harvest, clarification, concentration, purification strategy, recovery and troubleshooting.
→ 03Characterization & Analytics
Particle, physical, molecular and functional measurements designed around the development question.
→ 04Process Development & Scale-up
Risk-based development, parameter assessment, comparability thinking and technical decision support.
→YOUR SCIENTIFIC PARTNER
Satyabrata Pany, PhD
Founder & Principal Consultant
Experience across lentiviral and AAV vector systems, functional assays, analytical methods, process development, and scientific leadership.
Meet the founderHOW WE WORK TOGETHER
From a focused question to a practical plan.
Define the decision
Share your development stage, the challenge, and what your team needs to decide.
Agree on the scope
Identify the right format: an advisory call, technical review, development roadmap, or ongoing support.
Prioritize the next steps
Work toward evidence-based recommendations and a practical sequence of experiments or analyses.
FREE PROCESS DEVELOPMENT TOOLS
Check the numbers.
Question the assumptions.
Six practical LV calculators for MOI and vector volume, dilution, functional recovery, concentration, buffer exchange, and TFF pressure and flux. Explicit units and formulas keep the arithmetic transparent.
Open the calculatorsFREE TECHNICAL FIELD GUIDE
Before you scale,
pressure-test your process.
Lentiviral Vector Development Assessment
Review vector quality, process performance, analytical strategy and scale-up readiness. A ten-page framework with a fillable scorecard to help identify the technical questions worth resolving next.
WHAT TO REVIEW BEFORE SCALING
SCIENTIFIC INSIGHTS
Technical perspectives from our practice.
Overcoming the Transduction Titer Trap: Why Total Particle Counts Mislead Bioprocessing
Why physical particle measurements diverge from biological potency in lentiviral vectors, and how to calibrate the TU : vg ratio during downstream scale-up.
HEK293 Suspension Adaptation: Balancing Doubling Time and Transient Transducibility
Evaluating chemically defined media, viable cell density at transfection, and the impact of aggregation kinetics on lentiviral packaging.
Tangential Flow Filtration Shear Dynamics: Protecting Fragile Viral Envelopes
Comparing hollow fiber and flat sheet cassette geometries through functional recovery, process exposure, and evidence-based scale-up assessment.
BEFORE YOU REACH OUT
A few practical questions.
Not ready for a conversation? Start with the free development assessment.
Who is LentiWorks for?
Biotech, cell and gene therapy, and research teams developing, characterizing, troubleshooting, or scaling lentiviral vectors. Support is shaped around a specific technical question and complements your internal team.
Can we start with a single technical question?
Yes. Engagement options include advisory calls and focused technical reviews as well as program roadmapping and retained consulting. The scope is agreed around the decision you need to make.
Is LentiWorks a manufacturing provider?
No. LentiWorks provides independent scientific consulting, not CDMO manufacturing services. The focus is on production strategy, analytical interpretation, process development, and technical decision support.
What should I include in my first inquiry?
A short, non-confidential description of your challenge, current development stage, and desired outcome is enough. Please do not send proprietary sequences, unpublished datasets, or other sensitive information through the contact form.
A PRACTICAL SCIENTIFIC PARTNER
What does your team need to decide next?
Bring one development question. Let’s identify where independent scientific support can help.