LentiLENTIVIRAL VECTOR SCIENTIFIC CONSULTING
Build better vectors.
Understand what makes them work.
LentiWorks supports lentiviral vector development from upstream production through downstream processing, characterization, analytical strategy and scale-up.
VECTOR DEVELOPMENT
From particle production to functional performance.
Connect process variables, product attributes, analytical readouts and biological function to make development decisions with greater confidence.
THE LENTIWORKS APPROACH
Science first. Decisions second.
Lentiviral vector performance is not defined by a single number. LentiWorks helps connect production, purification, particle quality, functional activity and analytical data into a practical development strategy.
Whether troubleshooting inconsistent functional titer, evaluating a new production condition, developing a characterization package or preparing for scale-up, the goal is to identify what matters, test it efficiently and turn data into an actionable path forward.
CORE CAPABILITIES
Consulting across the LV development lifecycle.
Upstream Development
Production strategy, transient transfection, HEK293 systems, process optimization and scale considerations.
→ 02Downstream & Purification
Harvest, clarification, concentration, purification strategy, recovery and troubleshooting.
→ 03Characterization & Analytics
Particle, physical, molecular and functional measurements designed around the development question.
→ 04Process Development & Scale-up
Risk-based development, parameter assessment, comparability thinking and technical decision support.
→FREE TECHNICAL FIELD GUIDE
Before you scale,
pressure-test your process.
Lentiviral Vector Development Assessment
Review vector quality, process performance, analytical strategy and scale-up readiness. A ten-page framework with a fillable scorecard to help identify the technical questions worth resolving next.
WHAT TO REVIEW BEFORE SCALING
LATEST SCIENTIFIC INSIGHTS
Technical perspectives from our practice.
Overcoming the Transduction Titer Trap: Why Total Particle Counts Mislead Bioprocessing
Why physical particle measurements diverge from biological potency in lentiviral vectors, and how to calibrate the TU : vg ratio during downstream scale-up.
HEK293 Suspension Adaptation: Balancing Doubling Time and Transient Transducibility
Evaluating chemically defined media, viable cell density at transfection, and the impact of aggregation kinetics on lentiviral packaging.
Tangential Flow Filtration Shear Dynamics: Protecting Fragile Viral Envelopes
Comparing hollow fiber vs. flat sheet cassette geometries to minimize VSV-G glycoprotein shedding during high-concentration diafiltration.
A PRACTICAL SCIENTIFIC PARTNER
Need an independent perspective on your LV program?
Bring a development problem, analytical question or process challenge.